Red Light Therapy Device for Brain

1. 1050nm wavelength LED

2. Ntau zaus kho tau los ntawm 1 txog 20, 000 Hz

3. Kev teeb tsa zaus yog 30Hz. Ntau zaus tsis tshwm sim tab sis tuaj yeem hloov tau nrog cov nyees khawm.

4. Duration: tuaj yeem hloov kho los ntawm 0 mus rau 30 feeb

5. LED siv tau rau plaub theem: 25%, 50%, 75%, lossis 100%

6. suav nrog wireless chaw taws teeb tswj

7. Tag nrho cov zis siab tshaj plaws: 16W

8. Lub zog tso zis ntau tshaj ib LED: 50mW

9. tuaj yeem ua haujlwm manually lossis nrog cov chaw taws teeb tswj

11. Lub kaus mom hlau muaj 12 thaj tsam, txhua qhov kev hloov kho lub zog siv, zaus, thiab sijhawm teem sijhawm.

12. Tsis tas li muaj xws li qhov ntswg thiab pob ntseg applicators (tswj los ntawm tej thaj chaw deb), txhim kho kev kho mob efficiency.

Siv lub teeb ncaj qha rau ntawm tawv taub hau, tso cai rau photons nkag mus rau pob txha taub hau thiab ncav cuag cov ntaub so ntswg hlwb. Cov wavelengths tshwj xeeb, feem ntau yog nyob ze-infrared (1050nm), raug xaiv rau lawv cov peev xwm nkag mus tob.

Kev txo qis ntawm Oxidative Stress: PBM txo cov kev ntxhov siab oxidative los ntawm kev txhim kho cov haujlwm ntawm cov enzymes antioxidant. Oxidative stress yog ib qho tseem ceeb hauv kev degeneration ntawm dopaminergic neurons hauv Parkinson tus kab mob.

Neuroprotection thiab Neurogenesis: Neuroprotection: PBM tuaj yeem tiv thaiv cov neurons los ntawm apoptosis (cell tuag) los ntawm kev txo qhov mob thiab tiv thaiv kev sib sau ntawm cov proteins lom, xws li alpha-synuclein, uas cuam tshuam nrog cov kab mob Parkinson.

Neurogenesis: PBM tau pom tias yuav txhawb txoj kev loj hlob ntawm cov neurons tshiab thiab kho cov kab mob neuronal uas twb muaj lawm, uas tuaj yeem pab kho cov haujlwm poob.

Cytokine Modulation: PBM txo cov qib ntawm pro-inflammatory cytokines thiab tsub kom cov tshuaj tiv thaiv cytokines. Kev mob hauv lub hlwb, tshwj xeeb tshaj yog nyob rau hauv substantia nigra, pab txhawb kev loj hlob ntawm Parkinson's disease.

Microglial Activation: PBM tuaj yeem hloov kho kev ua haujlwm ntawm microglia (lub hlwb lub cev tiv thaiv kab mob), txo lawv cov kev cuam tshuam ntau dhau uas ua rau muaj kev puas tsuaj rau neuronal.

Txhim kho ntshav khiav: PBM txhim kho cov ntshav khiav thiab oxygenation hauv lub hlwb, ua kom cov neurons tau txais cov as-ham thiab oxygen lawv xav tau ua haujlwm zoo.

Vascular Function: PBM txhawb kev noj qab haus huv ntawm cov hlab ntsha hauv lub hlwb, uas tuaj yeem cuam tshuam rau tus kab mob Parkinson.

Cov txheej txheem

Nyob rau hauv ob qhov muag tsis pom kev, randomized, sham-tswj muaj peev xwm mus sib hais, cov neeg koom nrog hnub nyoog 59-85 nrog idiopathic Parkinson's kab mob tau kho nrog transcranial photobiomodulation (tPBM) kaus mom hlau rau 12 lub lis piam, tag nrho 72 zaug ntawm kev ua haujlwm lossis kev kho mob sham (theem 1) . Cov kev kho mob tau raug tswj xyuas hauv tsev, saib xyuas los ntawm kev sib tham hauv internet video (Zoom). Tom qab thawj 12 lub lis piam, cov neeg uas tau txais kev kho mob tsis muaj kev kho mob rau lwm 12 lub lis piam (cov pab pawg nquag-rau-tsis muaj kev kho mob), thaum cov neeg pib tau txais kev kho mob sham hloov mus rau 12 lub lis piam ntawm kev kho mob (sham-to-active pab pawg). yog lawv xaiv mus ntxiv (theem 2). Lub kaus mom hlau siv tau xa cov teeb liab thiab infrared rau lub taub hau rau 24 feeb, rau hnub hauv ib lub lis piam. Cov ntsiab lus tseem ceeb suav nrog kev nyab xeeb thiab lub cev muaj zog, ntsuas los ntawm kev hloov kho Movement Disorders Society Unified Parkinson's Disease Rating Scale Part III (MDS-UPDRS-III)-motor scale.



Kev tshawb pom

Txij Lub Kaum Ob Hlis 6, 2021, txog Lub Yim Hli 12, 2022, 20 tus neeg koom tau raug muab faib rau ob pawg (10 tus poj niam thiab 10 tus txiv neej hauv ib pab). Txhua tus neeg koom nrog hauv pab pawg nquag thiab 18 hauv pawg neeg txaj muag ua tiav 12-kev kho mob lub lim tiam. Kaum plaub tus neeg koom hauv pawg neeg txaj muag tau xaiv los hloov mus rau kev kho mob, thiab 12 ua tiav qhov 12-kev kho mob lub lim tiam. Kev kho mob tau txais txiaj ntsig zoo thiab ua tau, tsuas yog me me xwb, cov xwm txheej tsis zoo ib ntus. Ntawm cuaj qhov kev xav tias muaj xwm txheej tsis zoo, ob qhov kev cuam tshuam me me tuaj yeem muaj feem cuam tshuam nrog cov cuab yeej siv thaum lub sij hawm kho mob nyob rau hauv pab pawg sham-to-active. Ib tus neeg tuaj koom tau ntsib ib ntus ceg tsis muaj zog, thiab lwm tus tau tshaj tawm tias txo qis lub cev muaj zog zoo ntawm sab tes xis; ob leeg txuas ntxiv mus sim. Qhov nruab nrab hloov MDS-UPDRS-III cov qhab nia rau pawg sham-to-active ntawm lub hauv paus, tom qab 12 lub lis piam ntawm kev kho mob sham, thiab tom qab 12 lub lis piam ntawm kev kho mob yog 26.8 (sd 14.6), 20.4 (sd 12.8), thiab 12.2 ( sd 8.9), ib. Rau cov pab pawg nquag-rau-tsis-kev kho mob, cov txiaj ntsig no yog 21.3 (sd 9.4), 16.5 (sd 9.4), thiab 15.3 (sd 10.8), feem. Tsis muaj qhov sib txawv tseem ceeb ntawm cov pab pawg ntawm txhua qhov kev ntsuam xyuas. Qhov nruab nrab qhov sib txawv ntawm cov pab pawg hauv paus yog 5.5 (95% CI −2.4 txog 13.4), tom qab theem 1 yog 3.9 (95% CI −3.5 txog 11.3), thiab tom qab theem 2 yog −3.1 (95% CI 2.7 txog −10.6). .



Xaus

Peb qhov kev tshawb pom tau ua rau muaj pov thawj loj zuj zus tias tPBM yog ib qho kev nyab xeeb, zam tau, thiab ua tau tsis yog tshuaj kho mob rau tus kab mob Parkinson. Txawm hais tias kev tshawb fawb ntxiv yog qhov tsim nyog, peb cov txiaj ntsig tau teeb tsa lub hauv paus rau qhov loj dua, muaj peev xwm txaus siv cov tshuaj placebo tswj kev sim tshuaj.

Peb txoj kev tshawb fawb ntxiv rau lub cev ntawm cov pov thawj qhia tias transcranial PBM yog ob qho tib si kev nyab xeeb thiab muaj peev xwm kho tau rau Parkinson tus kab mob. Kev pom zoo txhim kho hauv cov cim qhia lub cev muaj zog, ua ke nrog cov ntaub ntawv los ntawm kev sim tshuaj yav dhau los thiab kev tshawb fawb tsiaj, qhia txog lub peev xwm ntawm tPBM raws li kev kho mob zoo nrog rau cov tshuaj dopamine. Kev tshawb nrhiav ntxiv tau lees paub, thiab txoj kev tshawb fawb no tau teeb tsa theem rau kev siv zog zoo randomized placebo-tswj tshuaj ntsuam xyuas yav tom ntej.